System Requirements for ChemOffice version 20.0


Hardware Component Minimum Specification Recommended Specification
Memory (RAM) For 32-bit OS 1 GB

For 64-bit OS 2 GB

For 32-bit OS 1 GB

For 64-bit OS 2 GB

Processor 1.6 GHz or higher 3.0 GHz or higher dual core processor
Free Space Required on Hard Drive 300 MB – 1 GB (1 GB is for installing the full ChemOffice Professional). This is for installation only and does not include any creation/expansion of any databases. 10 GB
Screen resolution 1024 x 768 or higher 1024 x 768 or higher


Software Windows Macintosh (ChemDraw Only)
Operating System
  • Windows 7 Professional and Ultimate (32-bit)
  • Windows 7 Professional and Ultimate (64-bit)
  • Windows 8.1 (64-bit)
  • Windows 10 (64-bit)
    • Mac OS X 10.15
    • Mac OS X 10.14
Microsoft Office (Standard, Professional, or Enterprise) Microsoft Office 2016 (32-bit and 64-bit)*1

  • Microsoft Office 2019 (32-bit and 64-bit)*1
  • Office 365*1

*1 The latest update used for testing is 2002 (12527.20278).

Note: We test with the latest versions of MS Office available at the time, but that is no guarantee of full compatibly with future updates.

  • Microsoft Office 2016*2
  • Microsoft Office 2019*2
  • Office 365*2

*2 The latest update used for testing is 16.35 (20030802).

.Net Framework .Net Framework 4.x N/A
Browser ActiveX controls: Microsoft Internet Explorer 11.x (32-bit and 64-bit) N/A

Note: The ChemDraw & Chem3D Plugins are no longer part of any ChemOffice/ChemDraw package. The ChemDraw & Chem3D ActiveX controls are still included with windows packages.

Product Compatibility

ChemDraw / ChemOffice 21.0 is qualified against the following:
• Windows 10 (64-bit)
• Windows 11 (64-bit)
• Microsoft Office 2019 (32-bit and 64-bit)
• Microsoft Office 2021 (32-bit and 64-bit)
• Microsoft Office 365 (32-bit and 64-bit)
• Mac OS X 11.6 (Big Sur)
• Mac OS X 12.1 (Monterey)
• Adobe Acrobat 11

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