The Merck Index 14th Edition

Latest version of the essential reference book includes searchable CD, and a new upgrade offers extensive structure search capabilities

With more than one million copies sold, The Merck Index has been the primary reference source for generations of professionals looking for precise, comprehensive information on chemicals, drugs and biologicals. The latest 14th Edition of this essential reference work for chemists, biochemists, pharmacists and related professionals, includes with the book, for the first time, a text-searchable CD-ROM, which contains all the data in the book and more. The CD contains ChemFinder, the industry-leading scientific search engine from CambridgeSoft Corporation (Cambridge, Massachusetts) that allows data to be searched by keywords, references and numerical properties.

The Merck Index is a one-volume encyclopaedia of chemicals, drugs and biologicals that contains more than 10,000 monographs, 32 supplemental tables, 450 Organic Name Reactions and more. This 14th Edition has been extensively revised to ensure its accuracy and enhance its readability with many new features as well as thousands of new references, trademarks and uses, plus an expanded – and timely – focus on “Green Chemistry” and compounds of environmental significance. In addition to revisions and updating, enhancements include embedding the Chemical Abstracts Registry Numbers for title and derivative compounds within the monographs.

CambridgeSoft, provider of previous electronic editions of The Merck Index, has made available The Merck Index 14th Edition/Chemists, an upgrade that provides the unique, powerful capability to search the CD to find molecules by fragment, sub-structures or full structures, on the basis of either exact matching or similarity. Structure searching is precise and convenient and includes tautomeric full and sub-structure searching. You can search for structures containing isotopic labels, or tetrahedral stereocenters, or other characteristics.

The Merck Index 14th Edition/Chemists, which is supplied by Adept Scientific (Letchworth, Herts.), provides the ability to search for alternative groups, either in atom labels such as “(OH,H,CONH2,Me)” or drawn using the R-Group features of ChemDraw (CambridgeSoft’s renowned structure drawing software, also available from Adept Scientific). Link nodes are supported, so you can search for variable-length rings and chains such as “(-CH2)6-8-” or multi-connected variables (“-R-“). You can now search for any type of single atom (“A, Q, X, M”) or any group (“R”).

Also included is an Personal Internet Edition subscription that provides immediate access to the data on the CD as well as updates. Together, the CD and the Internet Edition contain all the contents of the printed 14th edition plus nearly 1,000 monographs archived from previous editions.

All CambridgeSoft products, including the latest versions of ChemDraw, ChemOffice, Chem3D, BioDraw, BioOffice, BioAssay and E-Notebook as well as The Merck Index, are available from Adept Scientific.

With offices in the UK, USA, Germany and throughout the Nordic region, Adept Scientific is one of the world’s leading suppliers of software and hardware products for research, scientific, engineering and technical applications on desktop computers.

Introducing new ChemOffice Ultra 2005

Adept Scientific are pleased to announce the latest release of CambridgeSoft’s premier software suite for chemists and biologists.

New ChemOffice 2005 offers an unbeatable array of fully integrated applications and functionality, and is truly the ultimate desktop software suite any life scientist could desire. ChemOffice 2005 allows chemists to efficiently keep track of their work, gain a deeper understanding of their results, correlate biological activity with chemical structures, and of course most importantly: get their work done more professionally and effectively than ever before.

Powerful tools within the ChemOffice Ultra 2005 Suite
The three core applications of the ChemOffice suite are ChemDraw for structural drawing, Chem3D for modelling and visualisation, and ChemFinder, a chemical relational database application with full integration for Microsoft Excel and Word. The ChemDraw and Chem3D applications have been significantly updated in the new version – so too ChemFinder which now includes BioViz, a new bio-visualisation tool to correlate chemical data with biological activity. The new ChemOffice also includes updates to its structure searchable ChemFinder databases, including The Merck Index 13.2 edition, the ChemACX Database, which now offers over 330 catalogues from leading suppliers, and the ChemMSDX Database, which contains over 20,000 material safety data sheets for commonly used laboratory chemicals.

In addition to these updates there are a number of other exciting new components to the suite which really make this 2005 version of ChemOffice by far the best release yet. E-Notebook Ultra, Inventory Ultra and BioAssay Ultra, included in ChemOffice Ultra 2005, are all designed to deliver much of the functionality of CambridgeSoft’s enterprise level applications of these products to individual chemists at their desktops, without the need for a widespread roll out.

It’s impossible to list all the numerous features and benefits of ChemOffice 2005, so instead here’s a list of the highlights of the latest version.

Important new or enhanced features include:
Inventory Ultra 9.0 – Using MSDE as the database, users are given the opportunity to organise, store, and search over their inventory from their desktop. Includes the Available Chemicals eXchange, ChemACX Database, providing a complete tool for research chemical sourcing and purchasing.

BioAssay Ultra 9.0 – Provides flexible storage, retrieval, modelling and analysis of biological data – fit for the needs of both high and low throughput screening biologists.

BioViz/Office 9.0 – The bio visualisation add-on to ChemFinder allows users to create graphical representations of ChemFinder databases in order to identify trends within the data at a glance and evaluate diversity among compounds in a library. Plot styles include scatter plots, line charts, and histograms, with list colouring, point filtering, and more.

BioDraw Ultra 9.0 – Makes drawing and annotating biological pathways straightforward and quick, adding a level of uniformity and detail which is unmatched.

Properties LiveLink – Chemical names, formulae, molecular weights, and other physical properties added to the ChemDraw document are “live”, and will now update automatically as modifications are made to structural diagrams.

ChemNMR Improvements – Proton NMR spectra have more accurate chemical shifts and splitting patterns, and the predicted spectra are displayed more clearly for both Proton and Carbon-13 NMR predictions.

Improved Struct=Name feature – ChemDraw 9.0 now allows users to produce names for many more types of compounds, including charged compounds and salts, highly symmetric structures, many types of inorganic and organometallic compounds, and more.

ChemDraw Livelink – Simultaneous 2D & 3D editing! Draw structures using a ChemDraw window embedded in the Chem3D application. This powerful feature adds a 2D view that is always in-sync with the 3D view.

Dihedral Driver – Chem3D 9.0 provides a new conformational analysis tool that allows for the generation of MM2 energy plots by rotating one or two dihedral angles in the model. New GUI features also make Chem3D easier to use than ever!

Model Explorer – Hierarchical tree-control for exploring the structure of large models. Import a PDB file and examine chains, groups, and ligands. This new feature gives fine-grained control.

Multiple Projects – E-Notebook combines all your notebooks into one. Organise project notebooks the way you work.

Document Pages – E-Notebook pages contain Excel spreadsheets, Word documents, ChemDraw drawings and spectral data.

Audit Trail – E-Notebook 9.0 allows for a complete audit trial, retaining a complete copy of the experiment for each save, including username and timestamp. Other new E-Notebook features include the time saving AutoText feature, which allows users to add prewritten protocols to their experiment text.

Improved Excel integration – Now handling chemical structures in Microsoft Excel is even easier. Structure drawings are integrated with their spreadsheet cells, so they behave just like other data.

ChemOffice Ultra 2005 offers an impressive, comprehensive suite of programs designed to allow scientists to easily produce, store and share chemical and biological information, making this software package the ideal, integrated solution for escalating insight and efficiency in all scientific settings.

ChemOffice is supplied and supported in the UK by Adept Scientific plc, Amor Way, Letchworth, Herts. SG6 1ZA; telephone +44 (0) 203 695 7810, fax +44 (0) 203 695 7819, email info@alfasoft.com; or see Adept’s World Wide Web site http://www.adeptscience.co.uk/.

With offices in the UK, USA, Germany and throughout the Nordic region, Adept Scientific is one of the world’s leading suppliers of software and hardware products for research, scientific, engineering and technical applications on desktop computers.

New ChemOffice 2004 is Released

Adept Scientific plc announce the availability of ChemOffice 2004 from CambridgeSoft -the latest version of the ultimate PC office suite for chemists and biochemists, integrating Microsoft Office to provide the most comprehensive set of desktop tools for professionals today.

The three principal components of ChemOffice 2004—ChemDraw 8.0, Chem3D 8.0, and ChemFinder 8.0—all have exciting new features and improvements, the highlights of which are described below. ChemDraw prepares the structures (and chemical reaction diagrams too), Chem3D transforms them into 3D models for graphical examination and molecular modelling, and ChemFinder files the structures (or reactions) and their associated information in a chemically intelligent database.  Current users of ChemOffice know that the combined power of ChemDraw, Chem3D, and ChemFinder makes for a comprehensive and highly useful desktop chemistry suite to handle the chemist’s everyday needs, but ChemOffice 04 has even more to offer. In addition to constantly improving the utility and integration of the three applications, the ChemOffice team has been working on extending the integration of ChemOffice with Microsoft Office to provide the total package scientists need to manage business and chemistry from one desktop station.

The latest new features are summarised below:

ChemDraw 8.0

ChemDraw 8.0 has loads of new features to make it an ideal choice for anyone looking for a powerful, easy-to-use structure drawing and chemical information package:

* The new floating periodic table is the fastest route to element information, while the new floating character map enables users to add symbols and special characters from any font instantly to a ChemDraw document.

* A new TLC Plate drawing tool enables the reproduction of TLC plates in ChemDraw documents.

* Quickly examine potential mass fragments by breaking bonds with the brand-new Mass Fragmentation tool.

* New Struct=Name algorithm to generate systematic names from chemical structures, with comprehensive support for the Cahn-Ingold-Prelog (CIP) rules for absolute stereochemistry: a huge time saver!

* Improved Proton NMR predictions use splitting patterns to make predicted spectra look more realistic.

* Now you can rotate molecules and add perspective with simple 3D tools in ChemDraw 8.0.

Chem3D 8.0

New Chem3D 8.0 is the ultimate molecular modelling, visualisation and analysis suite boasting new features including:

* Produce detailed and realistic molecular models with enhanced graphics using OpenGL.

* The new depth perception features provide true perspective viewing, depth fading, and colour by-depth for stereo viewing.

* Now there’s no limit on molecule size in Chem3D, which means users can load and render models as large as their systems can handle.

* Includes usability enhancements, such as multilevel Undo/Redo and new export options for creating high quality images for publication and presentation.

ChemFinder 8.0

* Users can take advantage of ChemDraw and Chem3D ActiveX controls to present well rendered, fully interactive diagrams and models within a ChemFinder form.

* Search databases of 3D structures with queries specifying distances, angles, and other relationships between atoms, bonds, or group centroids.

* Generate combinatorial libraries within CombiChem/Excel or the easy new enumerator within ChemFinder/Office.

With more features then ever packed into ChemDraw, Chem3D and ChemFinder this is without a doubt the best ChemOffice ever. Even those familiar with ChemOffice will be delighted and amazed by this new version. Whether it’s used to create professional chemical drawings and documents, evaluate models and compute properties or manage chemical information, the new ChemOffice components will make chemists work more efficient and more effective.

With offices in the UK, USA, Germany and throughout the Nordic region, Adept Scientific is one of the world’s leading suppliers of software and hardware products for research, scientific, engineering and technical applications on desktop computers.

For the time being we are unable to offer the following product ranges although we are currently working hard to increase the number of products we can offer in the future. Please contact us to talk about alternative products that we may be able to offer you.