The Merck Index 14th Edition

Latest version of the essential reference book includes searchable CD, and a new upgrade offers extensive structure search capabilities

With more than one million copies sold, The Merck Index has been the primary reference source for generations of professionals looking for precise, comprehensive information on chemicals, drugs and biologicals. The latest 14th Edition of this essential reference work for chemists, biochemists, pharmacists and related professionals, includes with the book, for the first time, a text-searchable CD-ROM, which contains all the data in the book and more. The CD contains ChemFinder, the industry-leading scientific search engine from CambridgeSoft Corporation (Cambridge, Massachusetts) that allows data to be searched by keywords, references and numerical properties.

The Merck Index is a one-volume encyclopaedia of chemicals, drugs and biologicals that contains more than 10,000 monographs, 32 supplemental tables, 450 Organic Name Reactions and more. This 14th Edition has been extensively revised to ensure its accuracy and enhance its readability with many new features as well as thousands of new references, trademarks and uses, plus an expanded – and timely – focus on “Green Chemistry” and compounds of environmental significance. In addition to revisions and updating, enhancements include embedding the Chemical Abstracts Registry Numbers for title and derivative compounds within the monographs.

CambridgeSoft, provider of previous electronic editions of The Merck Index, has made available The Merck Index 14th Edition/Chemists, an upgrade that provides the unique, powerful capability to search the CD to find molecules by fragment, sub-structures or full structures, on the basis of either exact matching or similarity. Structure searching is precise and convenient and includes tautomeric full and sub-structure searching. You can search for structures containing isotopic labels, or tetrahedral stereocenters, or other characteristics.

The Merck Index 14th Edition/Chemists, which is supplied by Adept Scientific (Letchworth, Herts.), provides the ability to search for alternative groups, either in atom labels such as “(OH,H,CONH2,Me)” or drawn using the R-Group features of ChemDraw (CambridgeSoft’s renowned structure drawing software, also available from Adept Scientific). Link nodes are supported, so you can search for variable-length rings and chains such as “(-CH2)6-8-” or multi-connected variables (“-R-“). You can now search for any type of single atom (“A, Q, X, M”) or any group (“R”).

Also included is an Personal Internet Edition subscription that provides immediate access to the data on the CD as well as updates. Together, the CD and the Internet Edition contain all the contents of the printed 14th edition plus nearly 1,000 monographs archived from previous editions.

All CambridgeSoft products, including the latest versions of ChemDraw, ChemOffice, Chem3D, BioDraw, BioOffice, BioAssay and E-Notebook as well as The Merck Index, are available from Adept Scientific.

With offices in the UK, USA, Germany and throughout the Nordic region, Adept Scientific is one of the world’s leading suppliers of software and hardware products for research, scientific, engineering and technical applications on desktop computers.

Introducing new BioOffice Ultra 2005

Adept Scientific are pleased to announce the launch of CambridgeSoft’s BioOffice 2005: the ultimate suite for managing biological data.

With the addition of new and exciting biology-based desktop applications, CambridgeSoft has created a new suite of products especially for biologists called BioOffice. Combining the computing and analysis capabilities of BioAssay, BioViz, E-Notebook and Inventory, with the superior drawing and database capabilities of ChemDraw, Chem3D and ChemInfo, BioOffice is the ultimate suite for biological computing.

Included in BioOffice Ultra 2005…

BioAssay Ultra – the cornerstone of BioOffice, provides flexible storage, retrieval, and analysis of biological data. Designed for complex lead optimisation experiments, the software supports the quick set-up of biological models. Users model an assay mathematically in BioAssay to organise their data, perform automatic calculations and create plots.

BioViz/Chem & BioOffice – the ability to combine biological data with chemical structures is extremely important in any drug discovery environment. BioViz/Chem & BioOffice allows any user to analyse structure-related data combined with biological data visually. As an add-on to ChemFinder, this application provides a graphical representation of the data loaded into a ChemFinder form. Users can search over data and construct a scatterplot, histogram, or other useful data graphs of the resulting dataset. Plots are interactive to allow the selection and analysis of subsets of data.

E-Notebook Ultra – the most efficient and accurate way to write lab notebook entries as part of the daily work process. E-Notebook stores Microsoft Office documents, ChemDraw structures and reaction drawings, and related data in an electronic notebook that can be searched by text or chemical structure. Users organise pages by project, experiment, or according to their own style with Access. CombiChem/Excel builds combinatorial libraries.

Inventory Ultra – the desktop application designed to deliver much of the functionality of CambridgeSoft’s Enterprise level applications without a widespread rollout. Using MSDE as the desktop database, users are given the opportunity to organise, store and search over their inventory from their desktop. Inventory Ultra includes a copy of the ChemACX Database, providing a complete tool for research chemical sourcing and purchasing. It includes 350 major catalogues, from Alfa Aesar and Sigma Aldrich to TCI.

ChemDraw – allows users to easily draw chemical structures, featuring stereochemical intelligence, atom numbering, structure and style templates, a large choice of bonds and arrows, full colour drawing, and much more. These structures can be pasted into Microsoft Word documents, Excel documents, and PowerPoint presentations, to allow for professional looking journal articles, reports, and presentations.
Chem3D – this chemical modelling application provides realistic 3-dimensional quality renderings of complex chemical structures. Drag and drop structures from ChemDraw documents, calculate transition state geometries and physical properties with Fujitsu’s MOPAC, and add descriptive statistics and plots for structure-activity relationships with ChemSAR/Excel.

BioDraw – for drawing, annotating, sharing and presenting biological pathways. BioDraw makes it easy to draw biological pathways. Common pathway elements (membranes, DNA, enzymes, receptors, reaction arrows, etc.) are built in, and other elements can be imported. The pathways users create with BioDraw can be exported for use in presentations, grant proposals, and publications.

Scientific Databases – BioOffice 2005 includes a copy of ChemIndex Ultra, ChemRXN, NCI, and AIDS. The databases are searchable by chemical structure as well as molecular formula, molecular weight, and many other data fields. ChemINDEX is a directory of over 75,000 unique chemical substances, listing chemical structure, 3D structure, registry numbers, synonyms, physical properties, and links to Internet sources of further information. ChemRXN is a refined selection of over 29,000 fully atom-mapped reactions, including carefully selected reactions from InfoChem’s ChemSelect database and ISI’s ChemPrep database. National Cancer Institute (NCI) provides structures, names, and biological screening results from the Developmental Therapeutics Program (DTP), including DTP Human Tumour Cell Line Screen and DTP AIDS Antiviral Screen.

BioOffice will provide any biologist with the resources, tools and knowledge to dramatically improve the way they work and the quality of the results they produce.

BioOffice 2005 is supplied and supported in the UK by Adept Scientific plc, Amor Way, Letchworth, Herts. SG6 1ZA; telephone +44 (0) 203 695 7810, fax +44 (0) 203 695 7819, email info@alfasoft.com; or see Adept’s World Wide Web site http://www.adeptscience.co.uk/.

With offices in the UK, USA, Germany and throughout the Nordic region, Adept Scientific is one of the world’s leading suppliers of software and hardware products for research, scientific, engineering and technical applications on desktop computers.

For the time being we are unable to offer the following product ranges although we are currently working hard to increase the number of products we can offer in the future. Please contact us to talk about alternative products that we may be able to offer you.